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1. Journal of Cell and Tissue Research Vol. 25 (1): 7533-7537 (2025)
Healthy lifestyle slows epigenetic aging: Naturopathy offers insight
Gupta, P.D. and Sukumari, H.U.
Former Director Grade Scientist, Centre for Cellular and Molecular Biology, Hyderabad
E. mail: pdg2000@hotmail.com, Cell: 080728 91356
Abstract: Now it is established by various scientific experiments and epidemiological surveys that those who have adopted lifestyle in accordance to “biological clock” which in turn govern by natural factors, are leading healthy life compared to those who are leading so called “Modern Lifestyle”. In recent years, allopathy (ALP) and naturopathy (NAP) have become a favourite topic of discussion, the dispute remains active, and the debate over what to do about it continues. In recent years, even in allopathy medicine system rather than chemical drugs more “body friendly therapeutics” are being used, for example, gene therapy, cell therapy, stem cell implantation, biologics, and immunotherapeutic. With the better understanding of epigenetic naturopathy gained more importance. The therapeutic approach for any given disease should be adopted not on symptoms but on the basis of causes. And at last, as Ayurveda believes “Prevention is Better than Cure”, the “Eternal Truth” can guide us to remain healthy and disease free throughout our life span.
Keywords: Epigenetic Aging: Naturopathy
2 .Journal of Cell and Tissue Research Vol. 25(1): 7539-7541 (2025)
Immune response by the human body to SARS-COV 2 infection
Gupta, P.D.
Former Director grade Scientist, Centre for Cellular and Molecular Biology, Hyderabad. India
E. mail: pdg2000@hotmail.com, Cell: 08072891356
Abstract: Anew virus SARS-CoV 2 is responsible for Covid-19. In no time it became pandemic. Many existing drugs were tried but failed. It is a well known fact that our body fights against all infections and inflammations. Here we have described the immunological tools the body uses to prevent SARS-CoV2 infections.
Keywords: SARS-CoV 2
3. Journal of Cell and Tissue Research Vol. 25(1): 7543-7545 (2025)
Gut microbiota–Brain axis in neurological disorders
Gupta, P. and Gupta, P.D.
Department of Neurology, Wayne State University – Detroit Medical Center, Detroit, Michigan,
USA. E. mail: pdg2000@hotmail.com, Cell: 08072891356
Abstract: The gut microbiota–brain axis (GBA) is a bidirectional communication system between the gut and the central nervous system (CNS) that includes neural, endocrine, immune, and metabolic pathways. Evidence shows that alterations in the gut microbiota, contribute to the pathogenesis and progression of various neurological disorders, including Alzheimer’s disease (AD), Parkinson’s disease (PD), multiple sclerosis (MS) and stroke. This review presents the GBA and its role in neurological health and disease. We also discuss therapeutic approaches, including dietary interventions, probiotics, and fecal microbiota transplantation.
Keywords: Gut microbiota, Neurological disorders
4. Journal of Cell and Tissue Research Vol. 25(1): 7547-7552 (2025)
Toxic effects of micro-nano-plastics on human health
Badiger, S.S., Badami S., Mudhole, M. A. and Gupta, P.D.*
*Rtd. Director Grade Scientist, Center for Cellular and Molecular Biology, Hyderabad, 500007, India
Abstract: Plastic pollution, particularly in the form of microplastics (MPs) and nano-plastics (NPs), poses a significant threat to human health. These tiny particles result from the degradation of larger plastic items or are intentionally manufacturedare ubiquitous in the environment and can enter the human body through one or all three modes ingestion, inhalation, and skin contact. MPs and NPs are linked to a range of adverse health effects, including inflammation, oxidative stress, and disruption of normal organ functions. Studies have shown that these particles can accumulate in various tissues, including the gastrointestinal tract, cardiovascular system, and reproductive organs, leading to conditions such as inflammatory bowel disease (IBD), cardiovascular disease, impaired fertility and cancer. This review highlights the mechanisms of toxicity of MPs and NPs, their routes of exposure, and their impact on human health, underscoring the urgent need for further research and global action to reduce plastic waste, improve waste management, and regulate plastic exposure to safeguard public health.
Keywords: Plastic pollution
5. Journal of Cell and Tissue Research Vol. 25(1): 7553-7556 (2025)
Analysing the role of artificial intelligence in predicting mood of menopausal women
Tiwari, Nehaand Gupta, P. D.
Associate Professor, Dept. of CS & IT,IIS (deemed to be university), Jaipur.
Abstract: Predicting depression in menopausal women is a challenging and intricate task in the medical field. Hormonal changes during puberty, pregnancy, menstruation, and menopause make depression and mood swings more prevalent in women than in men. Menopause often leads to depression, which in turn causes both mental and physical health issues, making it a significant concern for women going through menopause. However, there have been only a limited number of studies focused on forecasting depression in women experiencing menopause because of its complexity. Artificial Intelligence (AI) driven analysis of human emotions ranges from capturing the subtle complexities of emotional expressions to addressing broader concerns. This paper focuses on the applications of AI in forecasting depression in menopausal women.
Keywords: menopausal women Mood prediction
6.Journal of Cell and Tissue Research Vol. 25(1): 7557-7561 (2025)
Estrogens play a hidden role in tumorigenesis
Gupta, P.D.
Former Director Grade Scientist, Centre for Cellular and Molecular Biology, Hyderabad
E. mail: pdg2000@hotmail.com, Cell: 080728 91356
Abstract: A balanced quantity of estrogenic compounds is very essential for heathy living for man and woman, The normal level of estrogen in females varies by age and physiological state, such as age, gender, and health history.Estrogen levels fluctuate throughout life of a woman, and it’s normal for them to rise and fall. For example, levels rise during puberty and ovulation, and dip during menstruation. Lately. in addition to its involvement in reproductive organs, estrogen regulates non reproductive tissues too. So far reports appeared deals with estradiol causing cancers in reproductive organs only but indications are there other organs too if not direct involvement, estrogens are involved indirectly in prostate, lung and colorectal cancers.
Keywords: Estrogens, Hormonal imbalance
7. Journal of Cell and Tissue Research Vol. 25(1): 7563-7567 (2025)
Sexual dimorphism in heart diseases
Gupta, P.D.
Former Director Grade Scientist, Centre for Cellular and Molecular Biology, Hyderabad.
E. mail: pdg2000@hotmail.com, Cell: 080728 91356
Abstract: Sexual dimorphism exists in Homo sapiens. Many physiological and pathological differences in gender are due to different hormonal milieu in males and females. Pathology of heart is regulated by hormonal levels circulating in the blood, among those, female sex steroid hormone, estradiol is main. Drastic changes in the levels of this hormone are seen in females only. Directly or indirectly estrogens are mainly involved in showing various aspects of cardiac functioning, genesis of diseases, testing and treatment in man and woman. Now clinicians have realized that both the genders should treated differently.
Keywords: Sexual dimorphism, Hormonal milieu
8. Journal of Cell and Tissue Research Vol. 25(1): 7569-7571 (2025)
Colorectal cancer: Regulated by gut’s clock
Gupta, P. D.
Former Director grade Scientist, Centre for Cellular and Molecular Biology, Hyderabad. India
E. mail: pdg2000@hotmail.com, Cell: 08072891356
Abstract: Biological clock is composed of proteins encoded by thousands of genes that switch on and off in a specific order. A master clock coordinates all the cellular biological clocks in an organism. It regulates an organism’s sense of time and controls many bodily functions. When particular group of cellular clocks go disarray, normal body functions go stray and can even produce cancer. In in vitro experiments scientists showed that intestinal barrier/ permeability functions are clock-dependent. A circadian rhythm disorder can be long-term and caused by aging, genes, or a medical condition. circadian rhythm disorder for huger can influence the progression of many diseases such as colorectal cancer
Keywords: Colorectal cancer, Gut’s clock
9. Journal of Cell and Tissue Research Vol. 25(1): 7572-75------ (2025)
Sexual dimorphism in medicine efficacy
Gupta, P.D.
Former, Director Grade Scientist, (Retired from Centre for Cellular and Molecular Biology, Hyderabad, India.
Abstract: Sexual dimorphism is the different characteristics in the same species, it exists deep down up to medicine efficacy. In other words, same medicine may not be efficient in man and woman equally for a particular disease;unfortunately, drug trails with these considerations. there is a lot of scope exists to do more research in this area.
Keywords: Sexual dimorphism, medicine efficacy
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