1. Electronic Journal of Pharmacology & Therapy, 4: 1-3 (2011)
TREATMENT OF RECALCITRANT DIABETIC ULCERS USING TRICHLOROACETIC ACID: A CASE REPORT
Nilforoushzadeh, M. A., Mansour, S., Nazli, A., Siadat, A. H. and Heidari, A.
Center for Research and Training in Skin Diseases and Leprosy, Tehran University of Medical Sciences, Tehran, Iran.. E mail: Amirhossein1@yahoo.com
Abstract: 15% of the diabetic patients are estimated to be affected by diabetic ulcer. This complication is usually caused by peripheral neuropathy or vascular insufficiency. Trichloroacetic acid (TCA) solution is regarded as an appropriate treatment for many of the cutaneous lesions. In the current case report, we present the therapeutic effect of TCA in the treatment of resistant diabetic ulcer.
Key words: Recalcitrant diabetic ulcers, Trichloroacetic acid
2. Electronic Journal of Pharmacology & Therapy, 4: 5-7 (2011)
CONTACT REACTIONS DUE TO ACHILLEA MILLEFOLIUM GEL USED IN THE TREATMENT OF CUTANEOUS LEISHMANIASIS
Jaffary, F., Nilforoushzadeh, M. A., Tavakoli, N., Zolfaghari, B. And Shahbazi, F.
Skin Disease and Leishmaniasis Research Centre, Isfahan University of Medical Sciences, Isfahan, Iran. E. mail: jaffary@pharm.mui.ac.ir .
Abstract: With global trend of using natural remedies in the prevention and treatment of diseases, safety of these herbal products is the major concern that needs to be evaluated. Achillea millefolium, a natural remedy of Asteraceae family, is used in many cultures as a diaphoretic, antipyretic, analgesic, anti-inflammatory, antispasmodic, diuretic, wound healing, antihaemorrhoides, and antimicrobial agent. Recently we conducted a randomized double blind clinical trial to evaluate the safety and efficacy of Achillea millefolium (yarrow) 5% gel (containing 5% poly phenol as active ingredient) compared with placebo in the treatment of acute cutaneous leishmaniasis caused by leishmania major.
Key words: Achillea millefolium, Cutaneous leishmaniasis
3. Electronic Journal of Pharmacology & Therapy, 4: 9-13 (2011)
PILOT OBSERVATION ON POSSIBLE AMELIORATIVE EFFECTS OF AQUEOUS EXTRACTS FROM BARK OF ALSTONIA SCHOLARIS ON BLEOMYCIN INDUCED CHROMOSOMAL DAMAGE IN IN VITRO CULTURED HUMAN LYMPHOCYTES
Chakraborty, S., Mistry, D. and Pithawala, M.
C. G. Bhakta Institute of Biotechnology, Uka Tarsadia University, Gopal Vidyanagar, Bardoli Mahua Road, Tarsadi, 394350. E. mail: meonis_pithawala@yahoo.com
Abstract: In present study possible ameliorative efficacy of aqueous extract of bark of Alstonia scholaris (ASE) in cultured human lymphocytes against Bleomycin-induced cytogenetic alterations has been reported. Cultures were treated either alone with Alstonia scholaris aqueous bark extract (50µg/ml) or in combination with radiomimetic drug Bleomycin (15µg/ml). Positive implications about radioprotective effects by Alstonia scholaris bark extract on Bleomycin induced cytogenetic alteration in the form of chromosomal aberrations in in vitro human lymphocyte culture was recorded.
Key words: Alstonia scholaris, Bleomycin, Human cytogenetics
4. Electronic Journal of Pharmacology & Therapy, 4: 15-20 (2011)
ANALYSES OF CERVICAL CANCER IN RAJKOT POPULATION
Dhruva, G.A., Agravat, A.H., And Bhojani, K.R.
Department of Pathology, Pandit Deendyal Upadhya Medical College, Rajkot 360 005.
E. mail: gadhruva@gmail.com
Abstract: Cervical malignancy is the second most common cancer in women worldwide, In present study, results of 400 Pap smears are analyzed, which had been examined in cytology section (Department of Pathology, P.D.U. Medical College, Rajkot) during 2 years time duration (2009-2010). All cervical smears collected and stained by Pap staining method. The smears were reported using The Bethesda system 2001. The commonest complaints observed during study were abnormal vaginal discharge (46.5%) and menstrual abnormalities (20.5%). According to classification of smears by Bethesda system, 18(4.5%) were unsatisfactory, 148(37%) were normal, 07(1.25%) had atrophic changes, 190(47.5%) were inflammatory, 03(0.75%) were ASCUS, 20(5%) were LSIL, 11(2.75%) were HSIL and 03(0.75%) were squamous cell carcinoma. , majority patients had 2 children 144(36%) and study showed that high parity was associated with higher occurrence of premalignant and malignant lesions of cervix. Pap smear is a simple, cheap, safe and practical diagnostic tool for early detection of cervical cancer in high risk group population and therefore should be established as routine screening procedure.Pap smear is a valuable tool for investigation as a screening procedure in asymptomatic women and as a diagnostic procedure in symptomatic women.It also has an important role in diagnosis of inflammatory lesions including the identification of causative organism, atrophic changes, changes of radiation therapy and some rare tumors.It is recommended that reporting should be done by The Bethesda System as it improves the reproducibility and helps in identification of ASCUS and AGUS lesions and plays a key role to diagnose various intraepithelial lesions and invasive lesions at an early stage and manage them properly.
Key words: Cervical smears, Pap stain, Bethesda
5. Electronic Journal of Pharmacology & Therapy, 4: 21-23 (2011)
XYLANASE PRODUCTION BY ASPERGILLUS NIGER FERMENTED IN WHEAT BRAN AND RICE STRAW
Velmurugan, R. and Divya, S.
Department of Biotechnology, Sri Sankara College of Arts and Science, Enathur Kanchipuram 631 561. Tamilnadu. E. mail: velbiofan@gmail.com
Abstract: In the present study the efficiency of xylanase production by Aspergillus niger was tested using agro wastes like wheat bran and rice straw. From the fermentation studies wheat bran gave the best result with an enzyme activity value of 0.0843 IU/ml. While rice straw gave an enzyme activity value of 0.0680 IU/ ml. The agro waste gave their maximum enzyme activities at about the 12 th hour, which is the maximum time when the enzyme may be harvested.
Classification of microarray data using support vector machine
Tintu, T. and Venkatesan, P.
Department of Community Medicine, C. U. Shah Medical College, Surendranagar 363001 Gujarat;.
E. mail: thomas.tintu@gmail.com
Abstract: Micro arrays are useful to find out the interaction between diverse pathologic states at the gene level. By using micro arrays, researchers are able to measure the abundance of thousands of mRNA targets simultaneously. Identification and classification of set of genes out of these thousands is a problematic process. Major challenge in disease diagnosis from microarray data is the need for robust, accurate, classification models which are independent of the analysis techniques used and can combine data from different laboratories. The main aim of this study is to find the classification efficiency of SVM in expression data sets of M. tuberculosis.
Key words: Microarray, Support vector classification
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