4.Journal of Cell and Tissue Research Vol. 24(2): 7491-7493 (2024)
Progeria: rare condition that causes rapid ageing
Gupta, P. D.
Former Director grade Scientist, Centre for Cellular and Molecular Biology, Hyderabad. India
E. mail: pdg2000@hotmail.com, Cell: 08072891356
Abstract: Though Progeria is rare found only one in one million people, it is a serious disease, even today we do not have any treatment for it. Only mutation of one gene, the Lamin gene, makes all the difference. The newborns with the disorder appear to be healthy at birth but usually start to show signs of premature aging during their first one to two years of life; their growth rate slows and they don’t gain. Children with the condition have typical intelligence. However, their rapid aging causes distinct physical characteristics by which they can easily identified. They do die early, the average age of death is 14.5 years, generally by stroke or heart attack.
Keywords: Progeria, Early aging
5.Journal of Cell and Tissue Research Vol. 24(2): 7495-7507 (2024)
The indispensable role of bacteria in human life and environmental health
Gupta, P. D. Skiba, D. and Sawicka, B.*
*Department of Plant Production Technology and Commodities Science, University of Life Sciences in Lublin, Poland. E. mail: barbara.sawicka@up.lublin.pl
Abstract: Bacteria, among the earliest life forms on Earth, are integral to both human health and environmental ecosystems. They contribute to essential processes such as digestion, nutrient absorption, and immune defense, and play key roles in the biogeochemical cycles that sustain life. This paper explores the indispensable role of bacteria in human life and environmental health, emphasizing their contributions to digestion, nutrient absorption, immune protection, and ecosystem functioning. It also discusses advances in understanding the human microbiome and their implications for health and the rapeutic interventions.The study reviews existing literature on the human microbiome, probiotics, and the role of bacteria in environmental nutrient cycling. It analyses experimental evidence and case studies, particularly focusing on the impact of fecal microbiota transplantation (FMT) as a therapeutic tool. Metagenomic analysis techniques are examined to highlight the diversity and functionality of gut bacteria, Bacteria are found to be essential for breaking down food, providing vital nutrients, and protecting against pathogens. They play a critical role in maintaining a healthy immune system and are involved in the biogeochemical cycles necessary for ecosystem health. Metagenomic analysis reveals significant variations in bacterial populations associated with health and disease, emphasizing the importance of a balanced microbiota. FMT shows promise as an effective treatment for various diseases, including gastrointestinal, metabolic, and neurological disorders. Bacteria are crucial for human health and environmental stability. Maintaining a balanced microbiota is vital for overall well-being, and interventions such as probiotics and FMT can offer significant health benefits. Future research should focus on further understanding the complex interactions between bacteria and their hosts to develop targeted therapies for various health conditions.
Keywords: Bacteria, Human health,
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6.Journal of Cell and Tissue Research Vol. 24(2): 7509-7518 (2024)
Systemic lupus erythematosus managed by faecal microbiota transfer technology
Pushkala, K. and Gupta, P. D.*
*Former Director grade Scientist, Centre for Cellular and Molecular Biology, Hyderabad. India
E. mail: pdg2000@hotmail.com, Cell: 08072891356
Abstract: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease causing many pathological disorders such as, lupus nephritis, seizures and memory problems, heart problems including scarring, pericarditis myocarditis, vasculitis, blood clots due to high levels of certain autoantibodies referred to as antiphospholipid antibodies, low blood cell counts, musculoskeletal problems hematologic problems, pleurisy, atherosclerosis and coronary artery disease. Etiology and management of this disease is still ill defined. However, recently developed FMT therapeutic technique showed promise in controlling SLE and its variants in animal as well human models.
Keywords: Systemic lupus erythematosus, FMT therapeutic .
7.Journal of Cell and Tissue Research Vol. 24(2): 7519-7523 (2024)
Cancer treatment - Traditional vs. Modern approaches
Gupta Alpana and Gupta, P. D.
Senior Associate Director, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield CT, USA.
E. mail: Alpana_gupta@hotmail.com
Abstract: The landscape of cancer treatment has evolved significantly over the years, transitioning from traditional methods to more advanced and targeted therapies. Historically, cancer treatments mainly included surgery, radiation, and chemotherapy. These methods, while effective, often come with severe side effects and limited precision. In contrast, modern treatments such as immunotherapy, targeted therapy, and personalized medicine offer more precise and less invasive options. These innovations not only improve survival rates but also enhance the quality of life for patients. The shift from broad-spectrum treatments to more personalized and precise therapies marks a significant milestone in oncology, offering hope for more effective and less debilitating cancer care.
Keywords: Cancer treatment
